What is open and collaborative science, and what opportunities and challenges does it present for development in the Global South? OCSDNet will serve as a platform for researchers and practitioners to explore this overarching question. In this five-part blog series, we are pleased to present interviews with each of our network advisors: Mat Todd, Hebe Vessuri, Lidia Brito, Cameron Neylon and Apiwat Ratanawaraha. Each advisor brings unique perspectives, experiences and questions to the network, and will guide us through our collective journey of learning and reflection. We hope these discussions inspire you and we welcome your thoughts and responses in the comments sections.